Investigating how TDP-43 affects the immune response in neurodegenerative diseases
Effects of TDP-43 Pathology on Innate Antiviral Mechanisms in Neurodegenerative Disease
This study is looking at how a protein called TDP-43, which is connected to diseases like Alzheimer's and ALS, affects the body's ability to fight off viruses, and it’s using mice to see how problems with this protein might make the brain more vulnerable to infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10891454 on NIH RePORTER |
What this research studies
This research explores the role of TDP-43, a protein linked to neurodegenerative diseases like Alzheimer's and ALS, in regulating the body's antiviral immune response. It examines how TDP-43 mislocalization in brain cells can impact the expression of immune-related genes and the susceptibility to viral infections. By using mouse models, the study aims to understand the connection between TDP-43 dysregulation and the presence of viral pathogens in the brain, which may contribute to the progression of these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.
Not a fit: Patients with neurodegenerative diseases not associated with TDP-43 dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance antiviral responses in patients with neurodegenerative diseases.
How similar studies have performed: Previous research has shown that targeting TDP-43 and its pathways can yield promising results in understanding neurodegenerative diseases, indicating potential for success in this approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Jackvony, Stephanie — Weill Medical Coll of Cornell Univ
- Study coordinator: Jackvony, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.