Investigating how TCF1 affects memory T cell formation in various tissues
The role of TCF1 in CD8+ tissue resident memory T cell formation and maintenance across distinct tissues
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11066254
This study is looking at how a protein called TCF1 helps special immune cells, known as tissue-resident memory T cells, stay in places like your intestines and salivary glands to better protect you from infections that come back, with the hope of finding ways to strengthen your immune response against viruses.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11066254 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of T cell factor 1 (TCF1) in the formation and maintenance of tissue-resident memory T (TRM) cells, which are crucial for protecting the body against recurrent infections. The study aims to explore how TCF1 influences TRM cells in different tissues, such as the intestines and salivary glands, and how its various isoforms contribute to this process. By examining the transcriptional regulators involved, the research seeks to enhance our understanding of TRM biology, which is currently less understood compared to circulating memory T cells. This could lead to improved strategies for boosting the immune response against viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of viral infections or those at risk of recurrent infections who may benefit from enhanced immune responses.
Not a fit: Patients who do not have a history of viral infections or those with conditions that do not involve the adaptive immune system may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune system's ability to protect against viral infections by improving the formation of memory T cells.
How similar studies have performed: While the specific role of TCF1 in TRM cell biology is largely unstudied, there is a growing body of evidence suggesting that understanding transcription factors in immune responses has led to significant advancements in immunology.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VANDENBURGH, SARA ALISSA — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: VANDENBURGH, SARA ALISSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.