Investigating how TCF-1 affects T cell development and gene expression
Official title: Tools for reversible short-term degradation of TCF-1 to address its molecular functions
Funded at Mayo Clinic Arizona · NIH-10798260 · Data updated 2026-11-12
This study is looking at a protein called TCF-1 that helps T cells grow and develop, to see how its temporary breakdown affects how these cells work, which could help us learn more about T cell biology and find new ways to treat related conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $207,500 |
| NIH project number | 5R21AI176254-02 |
| Project ID | NIH-10798260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to T cell dysfunction or immune system disorders.
✕Less likely to help
Patients with non-immune related conditions or those who do not have T cell involvement in their disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of TCF-1, a protein crucial for T cell development, by exploring its reversible short-term degradation. The study aims to uncover how TCF-1 influences gene expression and chromatin accessibility during different stages of T cell maturation. By using advanced molecular techniques, researchers will analyze the effects of TCF-1 on progenitor cells and T cells, providing insights into its context-specific functions. This could lead to a better understanding of T cell biology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of T cell development and lead to new strategies for treating immune-related diseases.
How similar studies have gone: Previous research has shown promising results in manipulating T cell functions through molecular interventions, indicating potential success for this approach.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Gounari, Fotini — Mayo Clinic Arizona
- Study coordinator: Gounari, Fotini
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.