Investigating how TCF-1 affects T cell development and gene expression
Tools for reversible short-term degradation of TCF-1 to address its molecular functions
['FUNDING_R21'] · MAYO CLINIC ARIZONA · NIH-10798260
This study is looking at a protein called TCF-1 that helps T cells grow and develop, to see how its temporary breakdown affects how these cells work, which could help us learn more about T cell biology and find new ways to treat related conditions.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ARIZONA (nih funded) |
| Locations | 1 site (SCOTTSDALE, UNITED STATES) |
| Trial ID | NIH-10798260 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of TCF-1, a protein crucial for T cell development, by exploring its reversible short-term degradation. The study aims to uncover how TCF-1 influences gene expression and chromatin accessibility during different stages of T cell maturation. By using advanced molecular techniques, researchers will analyze the effects of TCF-1 on progenitor cells and T cells, providing insights into its context-specific functions. This could lead to a better understanding of T cell biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions related to T cell dysfunction or immune system disorders.
Not a fit: Patients with non-immune related conditions or those who do not have T cell involvement in their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of T cell development and lead to new strategies for treating immune-related diseases.
How similar studies have performed: Previous research has shown promising results in manipulating T cell functions through molecular interventions, indicating potential success for this approach.
Where this research is happening
SCOTTSDALE, UNITED STATES
- MAYO CLINIC ARIZONA — SCOTTSDALE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOUNARI, FOTINI — MAYO CLINIC ARIZONA
- Study coordinator: GOUNARI, FOTINI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.