Investigating how TAZ and YAP proteins affect DNA repair and treatment resistance in brain cancer.
Official title: Novel Roles of TAZ and YAP in DNA Damage Repair with 3D Genome Organization and the Therapeutic Resistance in Glioblastoma
Funded at Mayo Clinic Arizona · NIH-11145285 · Data updated 2026-11-12
This study is looking at how two proteins, TAZ and YAP, affect brain cancer cells in glioblastoma, with the hope of finding new ways to improve treatment for patients dealing with this tough-to-treat cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | June 3, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $439,965 |
| NIH project number | 5R01NS127922-03 |
| Project ID | NIH-11145285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with glioblastoma, particularly those experiencing treatment resistance.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research focuses on glioblastoma, a highly aggressive brain cancer known for its resistance to treatment. It aims to understand the roles of two proteins, TAZ and YAP, in the behavior of glioma stem-like cells, which contribute to tumor recurrence after therapy. By exploring how these proteins influence DNA damage repair mechanisms, the study seeks to uncover new therapeutic targets that could improve treatment outcomes for patients. The research employs advanced molecular biology techniques to analyze the interactions and effects of TAZ and YAP in cancer cells.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance the effectiveness of therapies for glioblastoma patients.
How similar studies have gone: Previous research has shown promising results in targeting similar molecular pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Bhat, Krishna Pl — Mayo Clinic Arizona
- Study coordinator: Bhat, Krishna Pl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.