Investigating how TAZ affects metabolism in healthy and insulin-resistant conditions
Role of TAZ in metabolic regulation in both normal and insulin resistant states
This study is looking at how a protein called TAZ helps control how our bodies use energy, especially in the liver, which could help us understand more about conditions like diabetes and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10988315 on NIH RePORTER |
What this research studies
This research aims to understand the role of a protein called TAZ in regulating metabolism, particularly in the liver, under both normal and insulin-resistant conditions. By using various molecular and genetic techniques, the researchers will explore how TAZ influences the metabolism of glucose and lipids, which are crucial for maintaining energy balance in the body. The study will involve experiments on mice to uncover the mechanisms by which TAZ affects metabolic processes, especially during fasting and feeding. This could lead to new insights into metabolic diseases like diabetes and cardiovascular disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with insulin resistance or metabolic disorders, such as type 2 diabetes or non-alcoholic fatty liver disease.
Not a fit: Patients who are not experiencing metabolic dysregulation or those without insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for metabolic diseases, improving health outcomes for patients with conditions like diabetes and cardiovascular disease.
How similar studies have performed: Other research has shown promising results in understanding metabolic regulation through similar molecular approaches, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Miao, Ji — Boston Children's Hospital
- Study coordinator: Miao, Ji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.