Investigating how tau tangles affect brain cell function in Alzheimer's disease.
Neuropathology in tauopathies stem from depolarization-induced alterations in the planar distribution of phosphoinositides
This study is looking at how tau tangles, which are linked to Alzheimer's disease, affect brain cells and their health, using fruit flies and mice to find out how these tangles cause problems in the brain, with the hope of discovering new ways to help people with Alzheimer's and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10875752 on NIH RePORTER |
What this research studies
This research explores the impact of tau tangles, which are commonly found in Alzheimer's disease, on brain cell health and function. Using fruit flies and mouse models, the study examines how these tangles lead to harmful changes in neurons, including increased cell excitability and calcium imbalance. The researchers aim to understand the mechanisms behind these changes, particularly focusing on the role of a specific messenger molecule, inositol trisphosphate (IP3), in exacerbating neurotoxicity. By identifying how tau tangles disrupt normal cellular processes, the research seeks to uncover potential therapeutic targets for Alzheimer's disease and related dementias.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who exhibit symptoms associated with tau pathology.
Not a fit: Patients with non-tau related forms of dementia or those without any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain cells from damage caused by tau tangles in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding tau pathology and its effects on neurons, indicating that this approach has potential for significant findings.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Venkatachalam, Kartik — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Venkatachalam, Kartik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.