Investigating how tau-related changes in blood vessels affect brain function
Assessing the Functional Consequences of Tau-Related Vasculature Changes using In Vivo Imaging
This study is looking at how a protein called tau affects blood vessels in the brain and how that might relate to memory problems in Alzheimer's disease, hoping to find new ways to help improve brain health for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10629255 on NIH RePORTER |
What this research studies
This research explores the impact of tau protein on blood vessel changes in the brain, particularly in relation to cognitive decline associated with Alzheimer's disease. By using advanced imaging techniques in mice that overexpress tau, the study aims to understand how these vascular changes influence blood flow and oxygen delivery to brain tissues. The findings could provide insights into the mechanisms behind neurodegeneration and cognitive impairment, potentially leading to new therapeutic strategies. Patients may benefit from a better understanding of how vascular health relates to cognitive function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those experiencing early cognitive impairment.
Not a fit: Patients with cognitive impairments unrelated to tauopathies or vascular changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating cognitive decline in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between vascular changes and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bennett, Rachel Elise — Massachusetts General Hospital
- Study coordinator: Bennett, Rachel Elise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.