Investigating how tau proteins spread in neurodegenerative diseases.
Tau-seed protein interactome and its role in neurodegenerative tauopathies
This study is looking at how certain tau proteins behave in diseases like Alzheimer's and aims to find out how they spread in the brain and affect nerve cells, which could help develop new treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11258284 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of tau proteins in neurodegenerative diseases, particularly Alzheimer's disease and other tauopathies. It aims to identify specific tau species that propagate through neuronal networks and interact with other proteins, such as Bassoon, which may influence tau's neurotoxic effects. By using advanced techniques like Mass Spectrometry, the study seeks to uncover the cellular mechanisms behind tau propagation and its impact on brain health. Patients may benefit from insights that could lead to new therapeutic strategies targeting tau-related pathologies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or other tauopathies.
Not a fit: Patients with neurodegenerative diseases not primarily associated with tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of tauopathies, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding tau pathology, indicating that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lasagna-Reeves, Cristian — Baylor College of Medicine
- Study coordinator: Lasagna-Reeves, Cristian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.