Investigating how tau proteins affect cellular protein balance in Alzheimer's disease
Mapping tauopathy-induced changes in subcellular proteostasis with compartment-targeted sensors
This study is looking at how tau proteins, which are connected to Alzheimer's disease, affect the balance of proteins in our cells, and it aims to find new ways to help keep those proteins healthy for people with Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10526120 on NIH RePORTER |
What this research studies
This research focuses on understanding how tau proteins, which are linked to Alzheimer's disease, disrupt the balance of proteins within cells. By using innovative sensors that target specific cell compartments, the study aims to monitor and analyze protein quality control in various organelles. The researchers will explore how the dysfunction of one organelle can impact others, providing insights into the interconnected nature of cellular health and aging. This approach could lead to new therapeutic strategies for preserving protein homeostasis in patients with Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it due to age or genetic factors.
Not a fit: Patients with non-neurodegenerative conditions or those without any cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cellular health and slow the progression of Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding protein aggregation in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Demontis, Fabio — St. Jude Children's Research Hospital
- Study coordinator: Demontis, Fabio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.