Investigating how tau protein spreads in Alzheimer's disease
LRP1-tau interactions and Alzheimer Disease
This study is looking at how a protein called tau interacts with a receptor in the brain to better understand how Alzheimer's disease spreads and causes symptoms, using brain samples from people with the condition to find new ways to help in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10891765 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between tau protein and a specific receptor, LRP1, in the context of Alzheimer's disease. It examines how misfolded tau proteins, which form neurofibrillary tangles, propagate through the brain and contribute to the progression of Alzheimer's symptoms. By studying brain samples from Alzheimer's patients, the research aims to uncover the mechanisms behind tau propagation and its relationship with neuronal loss. This could lead to new insights into how Alzheimer's disease develops and progresses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other types of dementia not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding tau propagation and its implications in Alzheimer's disease, indicating that this approach has potential for significant findings.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Strickland, Dudley K. — University of Maryland Baltimore
- Study coordinator: Strickland, Dudley K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.