Investigating how tau protein interacts with RNA in Alzheimer's disease
Pathological Implications of the tau-RNA Interaction
['FUNDING_R21'] · UNIVERSITY OF FLORIDA · NIH-11134864
This study is looking at how a protein called tau interacts with RNA in Alzheimer's disease and other brain disorders, to see if these interactions can help protect the brain or make things worse, which could lead to new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11134864 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between tau protein and RNA in the context of Alzheimer's disease and other neurodegenerative disorders. It aims to understand how these interactions may contribute to the accumulation of tau and its associated toxicity. By examining RNA motifs that bind to tau at different stages of disease progression, the study seeks to identify whether these interactions can either protect against or promote the development of tau-related pathology. The findings could provide insights into the mechanisms of Alzheimer's disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at various stages of Alzheimer's disease, from those with no symptoms to those diagnosed with the condition.
Not a fit: Patients with tauopathies unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting tau-RNA interactions.
How similar studies have performed: While the specific focus on tau-RNA interactions is relatively novel, similar studies have shown promise in understanding tau pathology in neurodegenerative diseases.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOREN, JOHN — UNIVERSITY OF FLORIDA
- Study coordinator: KOREN, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease