Investigating how tau protein changes contribute to Alzheimer's disease
Emerging Role of Tau Citrullination During Alzheimer’s disease and Tauopathies
This study is looking at how a change in a protein called tau might play a role in Alzheimer's disease, using both animal models and human samples to help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11081782 on NIH RePORTER |
What this research studies
This research explores the role of a specific modification of tau protein, known as citrullination, in the development of Alzheimer's disease and related disorders. By examining how this modification affects tau's structure and function, the study aims to uncover new insights into the mechanisms behind tauopathies. The researchers will use both animal models and human samples to analyze the effects of tau citrullination on disease progression and pathology. This could lead to a better understanding of Alzheimer's and potentially identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related tauopathies.
Not a fit: Patients with other forms of dementia that do not involve tau protein aggregation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding tau modifications, but this specific focus on citrullination is relatively novel.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Lee, Daniel Carl — University of Kentucky
- Study coordinator: Lee, Daniel Carl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.