Investigating how tau protein changes contribute to Alzheimer's disease
Using a novel mTBI model to investigate phosphorylation dependent common mechanisms in tauopathies
This study is looking at how changes to a protein called tau might contribute to Alzheimer's disease, using a special mouse model to find out if targeting early changes in tau could help stop the disease from getting worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11034051 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular processes that lead to modifications of tau protein, which is crucial in the development of Alzheimer's disease and related dementias. By using a novel mouse model, the researchers aim to explore how specific phosphorylation events of tau can lead to its mislocalization and subsequent synaptic dysfunction. The study seeks to identify early tau phosphorylation events that could be targeted to prevent the progression of tau-related pathologies. This approach is grounded in previous findings that link these modifications to the early stages of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-tauopathies or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that prevent or slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting tau modifications, indicating potential for success in this novel approach.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Liao, Dezhi — University of Minnesota
- Study coordinator: Liao, Dezhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.