Investigating how tau protein changes affect brain cell health in Alzheimer's disease
Tau Post-Translational Modifications and Mitochondrial Quality Control
This study is looking at how changes to a protein called tau might contribute to Alzheimer's disease and other brain conditions, and it's for anyone interested in understanding how these changes can affect the health of brain cells as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10816556 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of tau protein modifications in the development of Alzheimer's disease and other neurodegenerative conditions. It examines how specific changes to tau, such as phosphorylation and acetylation, can impair its function and negatively impact the health of neurons. The study aims to uncover the mechanisms by which these modified tau proteins affect mitochondrial quality control, which is crucial for maintaining neuronal health. By exploring these relationships, the research seeks to fill critical knowledge gaps regarding the impact of tau on brain cell function and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing neurodegenerative conditions related to aging.
Not a fit: Patients with non-neurodegenerative conditions or those without any cognitive impairment may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's disease by targeting tau modifications to improve neuronal health.
How similar studies have performed: Previous research has shown promising results in understanding tau's role in neurodegeneration, indicating that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Johnson, Gail V. W. — University of Rochester
- Study coordinator: Johnson, Gail V. W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.