Investigating how Tau protein breakdown affects Alzheimer's disease progression
Tau protein proteolysis signaling in Alzheimer's disease
This study is looking at how a protein called Tau behaves in Alzheimer's disease and how its changes might lead to brain cell loss, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10728202 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Tau protein in Alzheimer's disease, particularly how its breakdown and aggregation contribute to neuron loss and disease progression. The study will explore how different fragments of Tau protein can induce aggregation, which is a key feature of Alzheimer's pathology. By examining the effects of various proteases on Tau protein, the research aims to identify mechanisms that could lead to new therapeutic strategies for managing Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding Tau protein dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Huseby, Carol J. — Arizona State University-Tempe Campus
- Study coordinator: Huseby, Carol J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.