Investigating how tau protein affects gene regulation in cells
Official title: Phase separation of nuclear tau and its role in gene regulation
Funded at University of California, San Diego · NIH-10710398 · Data updated 2026-11-12
This study is looking at how a protein called tau, which is linked to Alzheimer's disease, works inside cells and how it might help control genes and keep our DNA safe, so it's for anyone interested in understanding more about Alzheimer's and the science behind it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $184,757 |
| NIH project number | 5R21AG079239-02 |
| Project ID | NIH-10710398 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to tau protein dysfunction, such as Alzheimer's disease or other neurodegenerative disorders.
✕Less likely to help
Patients without tau-related conditions or those who do not exhibit any neurodegenerative symptoms may not benefit from this research.
What this research studies
This research explores the role of tau protein, commonly associated with Alzheimer's disease, in the nucleus of cells. It aims to understand how tau can influence gene regulation through a process called phase separation, which may affect chromosome stability and DNA protection. The researchers will conduct various laboratory experiments, including biophysical assays and cell-based studies, to uncover the molecular mechanisms behind tau's functions. By examining how tau behaves in the presence of nucleic acids and other proteins, the study seeks to provide insights into its potential roles in cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting DNA and regulating gene expression, which may have implications for treating neurodegenerative diseases.
How similar studies have gone: While the specific approach of investigating tau's role in gene regulation through phase separation is relatively novel, there is existing research indicating that similar mechanisms involving protein interactions and gene regulation have shown promise in other contexts.
Where this research is happening
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University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Debelouchina, Galia — University of California, San Diego
- Study coordinator: Debelouchina, Galia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.