Investigating how tau protein affects cellular clearance in Alzheimer's disease
A TFEB and V-ATPase-mediated lysosomal stress sensing pathway in tauopathy
This study is looking at how a protein called TFEB helps get rid of harmful tau protein clumps that are connected to Alzheimer's disease, with the hope of finding new ways to help people with this condition feel better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11051224 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called TFEB in the clearance of tau protein aggregates, which are linked to Alzheimer's disease and other neurodegenerative conditions. By studying mouse models of tauopathy, the researchers aim to uncover how tau pathology influences TFEB's function and its signaling pathways. The goal is to identify potential therapeutic strategies that could enhance the body's ability to clear these harmful tau aggregates, potentially improving outcomes for patients with Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related tauopathies.
Not a fit: Patients with non-tau related forms of dementia or neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cellular clearance of tau protein aggregates, potentially slowing the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting lysosomal pathways for neurodegenerative diseases, suggesting that this approach may hold significant potential.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Zheng, Hui — Baylor College of Medicine
- Study coordinator: Zheng, Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.