Investigating how tau protein affects brain cell function in Alzheimer's disease
Local protein synthesis in tau pathology neurodegeneration
['FUNDING_R01'] · WAYNE STATE UNIVERSITY · NIH-10990772
This study is looking at how a protein called tau affects brain cells in people with Alzheimer's disease, hoping to find early signs of changes that could help us create better treatments and support for patients before their memory gets worse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10990772 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of local protein synthesis in the brain's neurons, particularly how tau protein impacts synaptic function in Alzheimer's disease. The study aims to identify early molecular changes that occur before significant cognitive decline, which could lead to new therapeutic targets. By examining the relationship between tau pathology and synaptic alterations, the research seeks to uncover mechanisms that contribute to the progression of Alzheimer's disease. Patients may benefit from insights that could lead to earlier interventions and improved treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early-stage Alzheimer's disease or those at risk for developing Alzheimer's-related dementias.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia unrelated to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that prevent or slow cognitive decline in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of protein synthesis in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK, JOONGKYU — WAYNE STATE UNIVERSITY
- Study coordinator: PARK, JOONGKYU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease