Investigating how tau protein affects brain activity in Alzheimer's disease
The Role of the Tau in Homeostatic Scaling and Mechanisms of Alzheimer's Disease
This study is looking at how a protein called tau affects brain cell activity in Alzheimer's disease, with the hope of finding new ways to help improve the lives of people living with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11020946 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of tau, a protein associated with Alzheimer's disease, in regulating neuronal network activity. By examining how tau interacts with other proteins and influences synaptic plasticity, the study aims to uncover new insights into the mechanisms of Alzheimer's disease. The researchers will use advanced techniques such as live neuron imaging and mass spectrometry to analyze tau's behavior in neuronal cultures that model Alzheimer's. The ultimate goal is to identify potential therapeutic strategies that could improve outcomes for patients with Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve brain function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding tau's role in Alzheimer's, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Morris, Meaghan O'malley — Johns Hopkins University
- Study coordinator: Morris, Meaghan O'malley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.