Investigating how tau buildup affects memory and sleep in older adults at risk for Alzheimer's disease
Circuit-specific tau burden and mechanisms of sleep-dependent memory processing in older adults at risk for Alzheimer’s disease
This study is looking at how the buildup of a protein called tau in certain parts of the brain affects memory and sleep in older adults who might be at risk for Alzheimer's disease, and it involves some brain scans and sleep tests to help us understand this better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10539903 on NIH RePORTER |
What this research studies
This research explores the relationship between tau protein accumulation in specific brain circuits and its impact on memory processing and sleep in older adults who are at risk for Alzheimer's disease. By using advanced imaging techniques and sleep monitoring, the study aims to understand how tau affects both emotional and non-emotional memory functions. Participants will undergo neuroimaging and polysomnography to assess brain activity and sleep patterns, providing insights into the mechanisms behind memory impairment associated with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for Alzheimer's disease and may be experiencing memory issues.
Not a fit: Patients who are not at risk for Alzheimer's disease or who do not have memory concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for memory loss in older adults at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of tau in cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Yassa, Michael a — University of California-Irvine
- Study coordinator: Yassa, Michael a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.