Investigating how targeting aging could prevent Alzheimer's disease.
Targeting Aging to prevent Alzheimer's Disease: the Geroscience Approach
['FUNDING_R01'] · BUCK INSTITUTE FOR RESEARCH ON AGING · NIH-10820570
This study is looking at how getting older might affect the proteins in our brains that are linked to Alzheimer's disease, and it hopes to find new ways to slow down or prevent dementia, so people with Alzheimer's can join trials testing promising new treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BUCK INSTITUTE FOR RESEARCH ON AGING (nih funded) |
| Locations | 1 site (NOVATO, UNITED STATES) |
| Trial ID | NIH-10820570 on ClinicalTrials.gov |
What this research studies
This research explores the connection between aging and Alzheimer's disease, focusing on how age-related changes in proteins may contribute to the development of dementia. By examining the role of toxic proteins like beta-amyloid and tau, the study aims to identify potential interventions that could slow or prevent the onset of Alzheimer's. The approach is based on the concept of 'geroscience,' which suggests that addressing the aging process itself may lead to breakthroughs in treating chronic diseases like Alzheimer's. Patients may be involved in trials testing new compounds that target these aging-related mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over the age of 65, who are at risk for or showing early signs of Alzheimer's disease.
Not a fit: Patients who are younger than 65 or those who do not have any risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or delay the onset of Alzheimer's disease in older adults.
How similar studies have performed: Previous research has shown promise in targeting aging processes to address chronic diseases, suggesting that this approach may yield significant advancements in Alzheimer's treatment.
Where this research is happening
NOVATO, UNITED STATES
- BUCK INSTITUTE FOR RESEARCH ON AGING — NOVATO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LITHGOW, GORDON J — BUCK INSTITUTE FOR RESEARCH ON AGING
- Study coordinator: LITHGOW, GORDON J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease