Investigating how targeting aging cells can affect breast cancer development
Targeting Senescence and the senescent secretome to impact breast cancer formation
This study is looking at how aging cells might help cause breast cancer and will test if special drugs that get rid of these cells can lower the chances of developing tumors, which could lead to new ways to prevent breast cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10942512 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of senescence, or aging cells, in the development of breast cancer. By using a specific breast cancer model that involves irradiating mammary fat pads and implanting certain cells, the researchers aim to explore how senescent cells contribute to tumor formation. They will test the effects of senolytic drugs, which are designed to eliminate these aging cells, to see if this can reduce the incidence of tumors. This approach could provide insights into new prevention strategies for breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for breast cancer, particularly those with a family history or genetic predisposition.
Not a fit: Patients who are currently diagnosed with advanced breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reduce the risk of breast cancer by targeting aging cells.
How similar studies have performed: Other research has shown promising results in targeting senescent cells to improve health outcomes, suggesting this approach could be effective.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Korkola, James — Oregon Health & Science University
- Study coordinator: Korkola, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.