Investigating how targeting a specific protein can improve muscular dystrophy in mice
Targeting PTEN to ameliorate muscular dystrophy in a mouse model
This study is looking at how a protein called PTEN affects muscle growth in Duchenne muscular dystrophy (DMD) and hopes to find new ways to help improve muscle health for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11134503 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the PTEN protein in Duchenne muscular dystrophy (DMD), a severe muscle-wasting disease. By using a mouse model, the study aims to explore how inhibiting PTEN can enhance muscle growth and repair, potentially leading to new treatment strategies for DMD. The researchers will investigate the cellular mechanisms involved and assess the effects of PTEN targeting on muscle function and pathology in these mice. The ultimate goal is to translate these findings into therapeutic options for patients suffering from DMD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Duchenne muscular dystrophy or related muscular dystrophies.
Not a fit: Patients with muscular dystrophy types that do not involve PTEN dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve muscle function and quality of life for patients with muscular dystrophy.
How similar studies have performed: Previous studies have shown promising results in targeting PTEN for muscle repair, indicating potential for success in this approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Kuang, Shihuan — Duke University
- Study coordinator: Kuang, Shihuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.