Investigating how T-type calcium channels affect morphine's impact on the brain
The role of T-type calcium channels in the morphine effects in the nonspecific thalamus
This study is looking at how certain channels in the brain affect how morphine works and how it can lead to addiction, with the hope of finding new ways to help prevent people from misusing opioids.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10889172 on NIH RePORTER |
What this research studies
This research explores the role of T-type calcium channels in the nonspecific thalamus and their influence on the effects of morphine and opioid addiction. By using advanced techniques like patch-clamp recordings and 2-photon calcium imaging, the study aims to understand how morphine exposure alters neuronal excitability and behavior related to addiction. The research involves both ex vivo brain slice experiments and in vivo behavioral models to assess the impact of morphine on specific brain regions. The ultimate goal is to identify new therapeutic strategies for preventing opioid overuse.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of opioid use or those at risk of developing opioid addiction.
Not a fit: Patients who do not use opioids or have no history of substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for opioid addiction and improve strategies for managing pain without the risk of addiction.
How similar studies have performed: While the specific role of T-type calcium channels in morphine effects is less explored, similar research on calcium channels in addiction has shown promising results.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Timic Stamenic, Tamara — University of Colorado Denver
- Study coordinator: Timic Stamenic, Tamara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.