Investigating how T cells respond to inflammation in autoimmune diseases
Official title: T cell expression of inflammatory chemokine receptors
Funded at Brigham and Women's Hospital · NIH-11129403 · Data updated 2026-11-12
This study is looking at how immune cells called T cells move to inflamed areas in conditions like rheumatoid arthritis, with the hope of finding new ways to help manage these autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 15, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $735,372 |
| NIH project number | 1R01AR084627-01A1 |
| Project ID | NIH-11129403 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic autoimmune diseases, particularly those experiencing rheumatoid arthritis.
✕Less likely to help
Patients with acute inflammatory conditions or those not diagnosed with autoimmune diseases may not benefit from this research.
What this research studies
This research focuses on understanding how T cells, a type of immune cell, migrate to inflamed tissues in chronic autoimmune conditions like rheumatoid arthritis. By examining the expression of specific chemokine receptors on T cells, the study aims to identify the signals and factors that regulate their movement to sites of inflammation. Using advanced techniques such as CRISPR screens and spatial transcriptomics, researchers will explore the genetic and epigenetic mechanisms that control these receptors' expression. This could lead to new insights into how to better manage autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with autoimmune conditions by targeting the mechanisms that drive inflammation.
How similar studies have gone: Previous research has shown promising results in understanding T cell behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Rao, Deepak Angara — Brigham and Women's Hospital
- Study coordinator: Rao, Deepak Angara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.