Investigating how T cells interact with tumors and their environment
Official title: Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment
Funded at Broad Institute, INC. · NIH-11005699 · Data updated 2026-11-12
This study is looking at how T cells, which are important for fighting cancer, interact with tumor cells in their environment, using advanced tools to see how these T cells are organized and where they are located, with the hope of finding better ways to boost the body's immune response against cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $699,616 |
| NIH project number | 5R01CA276865-03 |
| Project ID | NIH-11005699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with various types of cancer who are undergoing or considering immunotherapy treatments.
✕Less likely to help
Patients with non-cancerous conditions or those not receiving immunotherapy may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between T cells and tumor cells within the tumor microenvironment. By utilizing advanced genomic tools, the study aims to analyze the clonal identity and spatial organization of T cells that infiltrate tumors. The researchers will employ innovative techniques such as single-cell TCR sequencing and Slide-seq technology to explore how T cell specificity influences their localization and effectiveness in fighting cancer. This comprehensive approach could lead to better insights into how to enhance anti-tumor immunity through immunotherapy.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy strategies that enhance the body's ability to fight cancer.
How similar studies have gone: Previous research has shown promising results using similar genomic and spatial analysis techniques in understanding tumor-immune interactions.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Chen, Fei — Broad Institute, INC.
- Study coordinator: Chen, Fei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.