Investigating how T cell responses differ in children with sepsis
Official title: T Cell Receptor Mediated T Cell Activation in Neonatal and Pediatric Sepsis
Funded at Feinstein Institute for Medical Research · NIH-11021943 · Data updated 2026-11-12
This study is looking at how the immune system's T cells work in kids with sepsis, especially comparing newborns to older children, to find ways to improve treatments for this serious condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $418,750 |
| NIH project number | 1R35GM157197-01 |
| Project ID | NIH-11021943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-21 years who are diagnosed with sepsis.
✕Less likely to help
Patients who are adults or do not have sepsis may not benefit from this research.
What this research studies
This research focuses on understanding how T cell memory influences the immune response in children suffering from sepsis, a severe condition caused by infections. The study aims to explore the differences in T cell activation between neonates and older children, as well as how these differences affect the severity of sepsis. By examining the interactions between T cells and antigen-presenting cells, the researchers hope to uncover mechanisms that could lead to better treatments for pediatric sepsis. The approach involves analyzing immune responses in various age groups to identify critical factors that contribute to sepsis outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for children with sepsis, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown that understanding immune responses in different age groups can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Taylor, Matthew David — Feinstein Institute for Medical Research
- Study coordinator: Taylor, Matthew David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.