Investigating how T-cell leukemia cells invade the central nervous system
Role of CXCR3-CXCL10 signaling in T-ALL CNS disease
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11061106
This study is looking at how T-cell acute lymphoblastic leukemia (T-ALL) cells move into the brain and spinal cord, which can make things worse for patients, and it hopes to find new ways to stop this from happening.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11061106 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how T-cell acute lymphoblastic leukemia (T-ALL) cells infiltrate the central nervous system (CNS), particularly the meninges, which is a significant factor in poor patient prognosis. The study examines the CXCR3-CXCL10 signaling pathway, which may facilitate the movement of these leukemic cells into the CNS. By utilizing advanced 3D cell culture techniques, the researchers aim to uncover the mechanisms behind this infiltration and how it relates to inflammation. The findings could lead to new therapeutic strategies to prevent or treat CNS involvement in T-ALL.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with T-cell acute lymphoblastic leukemia.
Not a fit: Patients with other types of leukemia or those outside the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent T-ALL cells from invading the CNS, potentially enhancing patient outcomes.
How similar studies have performed: While the specific focus on the CXCR3-CXCL10 pathway in T-ALL is novel, similar approaches have shown promise in understanding leukemic cell behavior in other contexts.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATLAWSKA-WASOWSKA, KSENIA — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: MATLAWSKA-WASOWSKA, KSENIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.