Investigating how synaptic vesicles transport neurotransmitters in the brain
Structural and functional investigations on synaptic vesicular transporters
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11045719
This study is looking at how a protein called SV2 helps brain cells communicate and how it might be affected by epilepsy and antiepileptic drugs, with the goal of finding better treatments for neurological conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11045719 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of synaptic vesicles in neurotransmitter release, which is crucial for communication between neurons in the brain. It aims to explore the function of a specific protein, SV2, that is involved in this process and is linked to conditions like epilepsy. Using advanced techniques such as cryo-electron microscopy and mass spectrometry, the research will investigate how SV2 operates and how antiepileptic drugs affect its function. This could lead to a better understanding of how to treat neurological diseases associated with transporter defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epilepsy or other neurological disorders linked to synaptic transporter dysfunction.
Not a fit: Patients with neurological conditions unrelated to synaptic vesicle transporters may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for epilepsy and other neurological disorders by enhancing our understanding of synaptic function.
How similar studies have performed: Previous research has shown promise in understanding synaptic transporters, but this specific investigation into SV2 is relatively novel.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, CHIA-HSUEH — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: LEE, CHIA-HSUEH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.