Investigating how surface texture affects blood vessel healing in new materials
Official title: Reactive Ion Plasma Treatment of Cardiovascular Biomaterials to Understand the Effect of Nanotopography on Endothelialization
Funded at San Jose State University · NIH-10671521 · Data updated 2026-11-12
This study is looking at how the texture of certain materials used in blood vessel grafts can help them heal better in your body, aiming to make these grafts safer and more effective for patients needing them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Jose State University NIH-funded |
| Lab location | 1 site (San Jose, United States) |
| Project start | September 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $146,500 |
| NIH project number | 5SC2GM140991-03 |
| Project ID | NIH-10671521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring vascular grafts, particularly those with conditions affecting blood flow.
✕Less likely to help
Patients who do not require vascular grafts or have contraindications for graft surgery may not benefit from this research.
What this research studies
This research explores how the surface texture of vascular graft materials influences the healing process of blood vessels. By using a technique called reactive ion plasma treatment, the study aims to improve a specific material known as polyvinyl alcohol (PVA) to enhance its compatibility with the body. The goal is to create vascular grafts that are less likely to fail due to blood clotting or tissue buildup, which are common issues with current synthetic grafts. Patients may benefit from improved graft materials that promote better healing and integration with their own blood vessels.
Why it matters
Potential benefit: If successful, this research could lead to more effective vascular grafts that reduce the risk of complications and improve patient outcomes.
How similar studies have gone: Previous research has shown promise in improving vascular graft materials through surface modifications, indicating potential for success in this approach.
Where this research is happening
-
San Jose State University
San Jose, United States Active
Researchers
- Principal investigator: Jurney, Patrick — San Jose State University
- Study coordinator: Jurney, Patrick
Related research
Other NIH-funded projects on the same topics.
-
Hormonal limits on heart cell division in mammalian hearts
This grant looks at why adult hearts can’t regrow after injury and explores how hormones, especially thyroid hormone, stop heart cells from dividing to help young hearts regenerate.
-
How the cell’s environment affects p53 and PTEN stability and clumping
This project looks at how the inside of cancer cells might push p53 and PTEN to misfold and form clumps, which could drive cancer progression.
-
Closed-loop Deep Brain Stimulation for Disrupting Abnormal Brain Signals in Alzheimer’s Disease
This grant funds research to test a smart, responsive brain stimulation approach to help people with Alzheimer’s-related brain changes feel fewer symptoms.
-
Diet-Driven Muscle Stem Cell Activation in Fruit-Fly Models
A basic science project aims to understand how diet affects muscle stem cells in a model system and what this could mean for muscle repair and aging in people.
-
Understanding Amyloid Fibril Formation in Diseases Using Space-Based Simulations
Researchers will use advanced computer models to study how tiny protein fibers that cause diseases like Alzheimer’s and type 2 diabetes start forming.
-
High-Definition 3D Printing Tool for Microfluidics at SJSU
A high-definition 3D printer will help San Jose State University researchers and students quickly build microfluidic devices for biology and biomedical education.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.