Investigating how SUMOylation affects Tau-related brain dysfunction in frontotemporal dementia.
Official title: Role of SUMOylation in Mitochondrial/Synaptic Axis Dysfunction Induced by Abnormal Tau in FTD
Funded at Columbia University Health Sciences · NIH-10930981 · Data updated 2026-11-12
This study is looking into how certain changes in proteins might affect thinking and behavior in people with frontotemporal dementia, using both animal models and neurons from patients to find new ways to help treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $666,920 |
| NIH project number | 5R01NS134902-02 |
| Project ID | NIH-10930981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with frontotemporal dementia or those with Tau mutations.
✕Less likely to help
Patients with other forms of dementia that do not involve Tau pathology may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind cognitive and behavioral impairments in frontotemporal dementia (FTD). It examines the role of SUMOylation, a process that modifies proteins, in controlling Tau protein aggregation and its harmful effects on mitochondrial and synaptic functions. The study utilizes animal models and patient-derived neurons to explore how these mechanisms contribute to the disease. By identifying how SUMOylation impacts Tau, the research aims to uncover potential therapeutic targets for FTD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive and behavioral symptoms in patients with frontotemporal dementia.
How similar studies have gone: Previous research has shown promising results in understanding Tau pathology and SUMOylation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Quinzii, Catarina M. — Columbia University Health Sciences
- Study coordinator: Quinzii, Catarina M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.