Investigating how SUMO2 affects DNA replication and transcription processes
RECQ5-dependent SUMO2 conjugation of PCNA in the resolution of transcription-replication conflicts
['FUNDING_R01'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-10558750
This study is looking at how a protein called SUMO2 helps another protein, PCNA, during the important processes of copying DNA and making RNA, which could help protect our cells from damage that might lead to problems like cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-10558750 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of SUMO2 in the process of DNA replication and transcription, particularly how it interacts with a protein called PCNA. Researchers will explore the molecular factors that trigger SUMO2 conjugation to PCNA during DNA synthesis and how this process helps resolve conflicts that can lead to DNA damage. By studying these interactions, the research aims to uncover mechanisms that protect cells from genomic instability, which is crucial for maintaining healthy cell function. Patients may benefit from insights gained about how to prevent or treat conditions related to DNA damage, such as cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a predisposition to cancers or those experiencing conditions related to DNA damage.
Not a fit: Patients with stable, non-cancerous conditions or those not affected by DNA damage may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing genomic instability, which is a key factor in cancer development.
How similar studies have performed: Other research has shown promising results in understanding the roles of SUMO proteins in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, YILUN — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: LIU, YILUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer