Investigating how sulfur amino acid metabolism affects liver health
Sulfur Amino Acid Metabolism and Regulation of Hepatic Metabolic Flexibility
This study is looking at how certain nutrients called sulfur amino acids affect liver diseases like non-alcoholic steatohepatitis (NASH), and it aims to find ways to improve liver health by understanding how these nutrients work in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10995323 on NIH RePORTER |
What this research studies
This research explores the role of sulfur amino acid metabolism in liver diseases, particularly non-alcoholic steatohepatitis (NASH). It aims to understand how disruptions in this metabolism can worsen liver conditions by studying genetic mouse models. The researchers will investigate the mechanisms that control sulfur amino acid metabolism and its impact on liver function, focusing on the availability of cysteine and its effects on fatty acid oxidation. By uncovering these relationships, the study seeks to provide insights into potential therapeutic targets for improving liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis or related liver conditions.
Not a fit: Patients with liver diseases unrelated to sulfur amino acid metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve liver function and reduce the severity of liver diseases like NASH.
How similar studies have performed: Previous research has shown that targeting metabolic pathways can lead to significant improvements in liver disease outcomes, suggesting this approach may be promising.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Li, Tiangang — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Li, Tiangang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.