Investigating how sulfatide deficiency contributes to brain changes in aging and Alzheimer's disease
Sulfatide deficiency: A novel mechanism leading to reactive astrogliosis in aging and Alzheimer’s disease
This study is looking at how a lack of a substance called sulfatide might contribute to brain inflammation in older adults and those at risk for Alzheimer's disease, especially focusing on people with a specific genetic factor, to help find new ways to support brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11051911 on NIH RePORTER |
What this research studies
This research explores the role of sulfatide deficiency in the development of reactive astrogliosis, a condition associated with neuroinflammation in aging and Alzheimer's disease. By studying the effects of sulfatide on brain health, particularly in individuals with the APOE4 genetic risk factor, the research aims to uncover new insights into the mechanisms of Alzheimer's disease. The approach includes using animal models to observe changes in brain function and inflammation related to sulfatide levels. The findings could lead to a better understanding of how aging affects brain health and the potential for new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those who carry the APOE4 allele and are at risk for Alzheimer's disease.
Not a fit: Patients who are younger or do not carry the APOE4 allele may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target sulfatide deficiency, potentially improving outcomes for patients with Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results in understanding the role of sulfatide in brain health, indicating that this research builds on established findings.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Han, Xianlin — University of Texas Hlth Science Center
- Study coordinator: Han, Xianlin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.