Investigating how sulfatide affects tau protein development in Alzheimer's disease
The role of sulfatide in the development of tauopathy in the context of ADRD
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11193445
This study is looking at how a brain fat called sulfatide might affect the buildup of tau protein, which is linked to Alzheimer's disease, and it aims to find ways to help delay or prevent dementia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11193445 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of sulfatide, a lipid found in the brain, in the development of tauopathy, which is associated with Alzheimer's disease and related dementias. The study will explore how the loss of sulfatide correlates with increased tau phosphorylation and its implications for brain function. Researchers will utilize various animal models to assess the impact of sulfatide levels on tau protein accumulation and the progression of Alzheimer's disease. By examining these relationships, the research aims to uncover potential therapeutic targets for delaying or preventing dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are at risk for Alzheimer's disease or have early signs of dementia.
Not a fit: Patients with non-neurodegenerative forms of dementia or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between lipid levels and tau pathology, suggesting that this approach may yield valuable insights.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAN, XIANLIN — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: HAN, XIANLIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.