Investigating how sugars affect blood clotting proteins in von Willebrand Disease
Official title: Role of glycans in VWF biology and VWD pathogenesis
Funded at Washington University · NIH-11016813 · Data updated 2026-11-12
This study is looking at how certain sugar molecules in the body affect a protein important for blood clotting, which could help us understand von Willebrand Disease better, and we’d love to involve patients by collecting samples or information to support our research.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 15, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $337,603 |
| NIH project number | 1P01HL173579-01A1 |
| Project ID | NIH-11016813 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with von Willebrand Disease or those with unexplained bleeding disorders.
✕Less likely to help
Patients with bleeding disorders unrelated to von Willebrand Factor or those without any coagulation issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of glycans, which are sugar molecules, in the biology of von Willebrand Factor (VWF) and the pathogenesis of von Willebrand Disease (VWD). The study will explore how specific changes in these glycans can influence the production and function of VWF, a crucial protein for blood clotting. By utilizing clinical and genomic resources, researchers aim to uncover the mechanisms by which glycosylation affects VWF levels and contributes to bleeding disorders. Patients may be involved in providing samples or data to help elucidate these relationships.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with von Willebrand Disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of glycosylation in blood disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: O'donnell, James — Washington University
- Study coordinator: O'donnell, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.