Investigating how sugars affect blood cell function and health
Official title: Core B: Glyco-genomics and Bioinformatics
Funded at Versiti Wisconsin, INC. · NIH-11001971 · Data updated 2026-11-12
This study is looking at how adding sugars to proteins affects the health and behavior of blood cells, helping us understand how these changes might influence blood cell function and development.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $232,706 |
| NIH project number | 5P01HL151333-05 |
| Project ID | NIH-11001971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting blood cell function, such as hematological disorders.
✕Less likely to help
Patients with non-hematological conditions or those not affected by blood cell function may not benefit from this research.
What this research studies
This research focuses on understanding how glycosylation, the process of adding sugars to proteins, influences the behavior and health of blood cells. By analyzing gene expression and the biological responses of these cells in various models, the study aims to uncover the relationships between sugar modifications and cell function. The research employs advanced techniques such as RNA sequencing to gather data from both bulk and single cells, which will be processed and analyzed to draw meaningful conclusions about blood cell maintenance and differentiation.
Why it matters
Potential benefit: If successful, this research could lead to new insights into blood cell disorders and potential therapeutic strategies.
How similar studies have gone: Previous research has shown promising results in understanding glycosylation's role in cell function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Weiler, Hartmut Karl-Heinz — Versiti Wisconsin, INC.
- Study coordinator: Weiler, Hartmut Karl-Heinz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.