Investigating how sugar-related changes affect immune responses in diabetes
Effects of Glycation and Carbonylation on MHC II-restricted immunity
This study is looking at how high sugar levels in people with type 2 diabetes can change the way their immune system works, specifically how it processes important signals for fighting off illnesses, and it aims to help us understand these changes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10763379 on NIH RePORTER |
What this research studies
This research focuses on understanding how glycation and carbonylation, which are modifications that occur in high sugar environments, impact the immune system's ability to process and present antigens. By studying patients with type 2 diabetes and using advanced techniques like mass spectrometry, the researchers aim to uncover how these modifications alter the function of MHC II proteins and T cell responses. The study will involve mapping these changes in both human subjects and animal models to provide insights into the underlying mechanisms affecting immunity in diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes or metabolic syndrome.
Not a fit: Patients without metabolic syndrome or type 2 diabetes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for immune-related complications in patients with type 2 diabetes.
How similar studies have performed: Previous research has indicated that understanding post-translational modifications can significantly impact immune responses, suggesting potential for success in this area.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Santambrogio, Laura — Weill Medical Coll of Cornell Univ
- Study coordinator: Santambrogio, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.