Investigating how structural variations in genes affect blood cell traits
Official title: Structural Variation and Hematological Traits
Funded at University of Washington · NIH-10840891 · Data updated 2026-11-12
This study is looking at how our genes affect the different types of blood cells, which can help doctors understand blood disorders and other health issues better, so patients can learn more about their blood health and any genetic risks they might have.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $687,693 |
| NIH project number | 5R01HL165061-02 |
| Project ID | NIH-10840891 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with known blood disorders or those interested in understanding their genetic predisposition to hematological conditions.
✕Less likely to help
Patients without any blood disorders or those not interested in genetic factors related to blood health may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that influence blood cell traits, such as red and white blood cells and platelets, which are crucial for diagnosing blood disorders and predicting various diseases. By utilizing advanced genome sequencing data and innovative software, the study aims to identify structural variations in genes that may contribute to these traits. The research will also employ gene-editing technologies to validate the findings, providing insights into the genetic architecture of complex blood-related conditions. Patients may benefit from a better understanding of their blood health and potential genetic risks.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and personalized treatment options for blood-related disorders.
How similar studies have gone: Previous research has shown success in identifying genetic factors related to blood traits, but this approach utilizing large-scale genome sequencing is relatively novel.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Reiner, Alexander P — University of Washington
- Study coordinator: Reiner, Alexander P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.