Investigating how structural racism affects kidney health in Black individuals with specific genetic risks
Official title: Structural Racism as a "Third hit" on kidney outcomes of Black individuals with APOL1 risk alleles
Funded at Icahn School of Medicine at Mount Sinai · NIH-11097370 · Data updated 2026-11-12
This study is looking at how structural racism affects kidney health in Black individuals with certain genetic risks, and it aims to find ways to improve care for those facing chronic kidney disease and kidney failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 23, 2024 |
| Project end | March 19, 2025 |
| Funding year | 2025 |
| Award (this year) | $194,886 |
| NIH project number | 5K23DK139454-02 |
| Project ID | NIH-11097370 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Black individuals with APOL1 high-risk alleles who are experiencing or at risk for chronic kidney disease.
✕Less likely to help
Patients who do not identify as Black or do not carry APOL1 high-risk alleles may not benefit from this research.
What this research studies
This research explores the impact of structural racism on kidney health outcomes among Black individuals who carry high-risk APOL1 alleles. It aims to understand how this form of racism, alongside other health risks like hypertension and HIV, contributes to the progression of chronic kidney disease (CKD) and kidney failure. The study will involve collaboration with a diverse group of stakeholders to analyze data and develop a patient-centered intervention designed to improve health outcomes. By addressing these complex factors, the research seeks to provide insights that could lead to better care strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved health interventions that mitigate the negative effects of structural racism on kidney health for Black individuals.
How similar studies have gone: While the specific focus on structural racism as a third hit in kidney health is novel, related research has shown that addressing social determinants of health can improve health outcomes in marginalized populations.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Mohottige, Dinushika — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mohottige, Dinushika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.