Investigating how stress responses in melanoma affect tumor growth and spread
The integrated stress response and the microenvironment in melanoma progression
This study is looking at how melanoma cells behave and survive in tough situations, which could help us find new ways to treat the disease and improve outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11005714 on NIH RePORTER |
What this research studies
This research focuses on understanding how melanoma cells interact with their surrounding environment, particularly under stress conditions. By examining the Integrated Stress Response (ISR) and its role in tumor progression, the study aims to uncover mechanisms that allow melanoma to survive and resist therapies. The researchers will utilize advanced mouse models to investigate the effects of specific genes on tumor behavior and response to treatment. Patients may benefit from insights that could lead to new therapeutic strategies targeting these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with malignant melanoma, particularly those with advanced or metastatic disease.
Not a fit: Patients with non-melanoma skin cancers or those who have not been diagnosed with melanoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for melanoma, potentially improving survival rates.
How similar studies have performed: Previous research has shown promising results in targeting stress responses in cancer, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Koumenis, Constantinos — University of Pennsylvania
- Study coordinator: Koumenis, Constantinos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.