Investigating how stress responses affect recovery after spinal cord injury
Official title: Cell type-specific effects of the integrated stress response pathway after traumatic spinal cord injury
Funded at University of Louisville · NIH-11132104 · Data updated 2026-11-12
This study is looking at how the body reacts at a cellular level after a spinal cord injury and how these reactions can either help or hurt recovery, with the goal of finding ways to protect the nerves and improve healing for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | May 5, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $591,304 |
| NIH project number | 1R01NS138333-01A1 |
| Project ID | NIH-11132104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who have experienced a traumatic spinal cord injury.
✕Less likely to help
Patients with chronic spinal cord injuries or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding the cellular responses that occur after a traumatic spinal cord injury (SCI) and how these responses can lead to further damage or recovery. It examines the role of specific proteins and inflammatory processes that contribute to the secondary injury following SCI. By studying the integrated stress response pathway, the research aims to identify potential neuroprotective strategies that could improve recovery outcomes for patients. The approach involves analyzing the activation of stress response pathways and their effects on different cell types involved in the injury process.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce damage after spinal cord injuries.
How similar studies have gone: Previous research has shown promise in targeting stress response pathways for neuroprotection in spinal cord injuries, indicating potential for success in this approach.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Hetman, Michal — University of Louisville
- Study coordinator: Hetman, Michal
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.