Investigating how stress responses affect recovery after spinal cord injury
Cell type-specific effects of the integrated stress response pathway after traumatic spinal cord injury
['FUNDING_R01'] · UNIVERSITY OF LOUISVILLE · NIH-11132104
This study is looking at how the body reacts at a cellular level after a spinal cord injury and how these reactions can either help or hurt recovery, with the goal of finding ways to protect the nerves and improve healing for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-11132104 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the cellular responses that occur after a traumatic spinal cord injury (SCI) and how these responses can lead to further damage or recovery. It examines the role of specific proteins and inflammatory processes that contribute to the secondary injury following SCI. By studying the integrated stress response pathway, the research aims to identify potential neuroprotective strategies that could improve recovery outcomes for patients. The approach involves analyzing the activation of stress response pathways and their effects on different cell types involved in the injury process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have experienced a traumatic spinal cord injury.
Not a fit: Patients with chronic spinal cord injuries or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce damage after spinal cord injuries.
How similar studies have performed: Previous research has shown promise in targeting stress response pathways for neuroprotection in spinal cord injuries, indicating potential for success in this approach.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HETMAN, MICHAL — UNIVERSITY OF LOUISVILLE
- Study coordinator: HETMAN, MICHAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.