Investigating how stress during DNA replication affects inflammation in aggressive breast cancer.
Activation of Inflammatory Responses Upon Replication Stress in Basal-Like Breast Cancer
This study is looking at a tough type of breast cancer called basal-like breast cancer and is testing how reducing a certain enzyme can help damage cancer cells and boost inflammation, with the hope of finding better treatments for patients facing this challenging condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11030256 on NIH RePORTER |
What this research studies
This research focuses on basal-like breast cancer, a particularly aggressive subtype that often resists treatment. The study examines how partial suppression of a specific enzyme involved in DNA replication, DNA polymerase epsilon, can lead to DNA damage and increased inflammation in cancer cells. By understanding these mechanisms, the research aims to develop more effective therapies that target the unique characteristics of basal-like breast tumors. Patients may benefit from new treatment strategies that could improve outcomes for this challenging cancer type.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with basal-like breast cancer who have limited treatment options.
Not a fit: Patients with other subtypes of breast cancer, such as luminal breast cancer, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with basal-like breast cancer.
How similar studies have performed: Other research has shown promising results in targeting specific molecular alterations in aggressive cancers, suggesting potential for success in this approach.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Gorodetsky, Elizabeth Frances — New York University School of Medicine
- Study coordinator: Gorodetsky, Elizabeth Frances
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.