Investigating how stress and alcohol affect brain function and metabolism
Project 7/8: INIA Stress and Chronic Alcohol Interactions: Cross-species studies of metabolic allostasis and altered striatal circuitry
This study is looking at how long-term heavy drinking and stress affect the brain, using special tools to see what happens in the brains of mice and monkeys, and it hopes to help people understand and treat issues related to alcohol use and stress better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11012908 on NIH RePORTER |
What this research studies
This research explores the effects of chronic heavy alcohol consumption and stress on brain function and metabolism. By using advanced techniques like electrophysiology and magnetic resonance spectroscopy (MRS), the study aims to understand how these factors influence neural circuits in both mice and nonhuman primates. Patients may benefit from insights into the neural mechanisms behind alcohol use disorder and stress-related cognitive impairments, potentially leading to better treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing alcohol use disorder or related cognitive impairments, particularly those affected by stress.
Not a fit: Patients who do not consume alcohol or do not experience stress-related cognitive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals struggling with alcohol use disorder and stress-related cognitive issues.
How similar studies have performed: Previous research has shown promising results in understanding the neural impacts of alcohol and stress, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Kroenke, Christopher D — Oregon Health & Science University
- Study coordinator: Kroenke, Christopher D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.