Investigating how stress affects lupus through a specific biological pathway
The Role of the Adrb3/IL6 Axis in the Impact of Psychosocial Stress on Lupus Pathogenesis
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10993089
This study is looking at how stress might affect lupus by exploring a specific pathway in the body, and it aims to find out if understanding this connection can help develop new treatments for people living with lupus.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10993089 on ClinicalTrials.gov |
What this research studies
This research explores the connection between psychosocial stress and systemic lupus erythematosus (SLE) by examining the Adrb3/IL6 pathway. It focuses on how stress triggers the production of IL6 from brown adipocytes, which may influence immune responses and disease outcomes in lupus. Using murine models, the study aims to uncover the biological mechanisms that link stress to increased immune activation in lupus, potentially leading to new therapeutic strategies. The findings could pave the way for translating these insights into human applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus who experience psychosocial stress.
Not a fit: Patients without a diagnosis of systemic lupus erythematosus or those not experiencing psychosocial stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of lupus flares triggered by stress.
How similar studies have performed: Other research has shown promising results in understanding the effects of stress on autoimmune diseases, making this approach both relevant and potentially impactful.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, ANDREW — YALE UNIVERSITY
- Study coordinator: WANG, ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.