Investigating how stress affects immune cells in cancer progression
Official title: Understanding the role of β2AR-signaling on ILC2 differentiation/plasticity and its implications in cancer progression
Funded at Roswell Park Cancer Institute Corp · NIH-10906024 · Data updated 2026-11-12
This study is looking at how chronic stress affects certain immune cells in cancer patients, specifically how stress hormones might change the way these cells work and impact cancer growth and treatment.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $33,792 |
| NIH project number | 5F30CA284763-02 |
| Project ID | NIH-10906024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are experiencing high levels of stress and may benefit from improved immune responses.
✕Less likely to help
Patients who are not currently undergoing cancer treatment or do not have elevated stress levels may not receive benefit from this research.
What this research studies
This research explores the impact of chronic stress on immune cells, specifically type II innate lymphoid cells (ILC2s), in the context of cancer. It focuses on how norepinephrine, released during stress, activates the β2-adrenergic receptor (β2AR) on these immune cells, potentially leading to an immunosuppressive tumor microenvironment. By examining the mechanisms of ILC2 differentiation and function, the study aims to uncover how stress influences cancer progression and treatment outcomes. The research employs preclinical models to analyze the relationship between β2AR signaling and tumor response.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing anti-tumor immune responses in cancer patients experiencing chronic stress.
How similar studies have gone: While the specific approach of this research is novel, previous studies have indicated that stress can negatively impact immune function in cancer, suggesting a potential for significant findings.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Choi, Jee Eun — Roswell Park Cancer Institute Corp
- Study coordinator: Choi, Jee Eun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.