Investigating how stress affects brain function through specific receptors.
Official title: Prefrontal impairment with stress- NE receptor subtype mechanisms.
Funded at Yale University · NIH-11013920 · Data updated 2026-11-12
This study is looking at how stress affects a part of the brain that helps with memory and decision-making, using monkeys to see how certain receptors in the brain respond during stressful situations, which could help us find better treatments for conditions like PTSD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $682,037 |
| NIH project number | 5R01MH130538-03 |
| Project ID | NIH-11013920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive impairments related to stress or mental health disorders, such as PTSD.
✕Less likely to help
Patients with cognitive impairments not related to stress or those who do not have access to the research facilities may not benefit from this research.
What this research studies
This research focuses on understanding how stress impacts the dorsolateral prefrontal cortex (dlPFC), a brain region crucial for working memory and decision-making. By examining the roles of different norepinephrine receptor subtypes, the study aims to identify how these receptors influence brain function under stress. Using advanced techniques in rhesus monkeys, researchers will observe neuronal activity and receptor interactions during cognitive tasks, which may reveal new insights into stress-related cognitive impairments. The findings could lead to more effective treatments for conditions like PTSD.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for stress-related cognitive deficits and mental health disorders.
How similar studies have gone: Previous research has shown promise in understanding the role of norepinephrine in stress and cognition, but this specific approach to receptor subtypes is novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Arnsten, Amy F.t. — Yale University
- Study coordinator: Arnsten, Amy F.t.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.