Investigating how stress affects brain circuits linked to sudden unexpected death in epilepsy.
Official title: CRH Dysregulation of Brainstem Autonomic Circuits Increases SUDEP Risk
Funded at Tufts University Boston · NIH-10992176 · Data updated 2026-11-12
This study is looking at how stress might play a role in sudden unexpected death in people with epilepsy by using specially designed mice to see how stress affects the brain areas that control heart and breathing functions, which could help us find new ways to understand and identify risks for those at risk of SUDEP.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 9, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $548,575 |
| NIH project number | 5R01NS102937-08 |
| Project ID | NIH-10992176 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with epilepsy, particularly those who may be at risk for SUDEP due to stress-related factors.
✕Less likely to help
Patients without epilepsy or those who do not experience stress-related complications may not benefit from this research.
What this research studies
This research explores the connection between stress and sudden unexpected death in epilepsy (SUDEP) by examining how hyperactive stress circuits in the brain may disrupt autonomic functions. Using genetically engineered mice, the study aims to understand how these stress circuits affect brainstem areas that control heart and respiratory functions. The findings could lead to insights into the neuroendocrine abnormalities observed in patients who have experienced SUDEP, potentially identifying new biomarkers for risk assessment.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for SUDEP, enhancing patient safety and outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of stress in SUDEP, but this specific approach is novel and aims to uncover new mechanisms.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Maguire, Jamie Lynn — Tufts University Boston
- Study coordinator: Maguire, Jamie Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.