Investigating how stomach cells interact with a common bacteria linked to cancer.
Official title: Project 2: Ex Vivo Modeling and Analysis of Gastric Precancerous Lesions
Funded at Stanford University · NIH-10932174 · Data updated 2026-11-12
This study is looking at how stomach stem cells interact with a bacteria called Helicobacter pylori to better understand why some people with a condition called gastric intestinal metaplasia (which can lead to stomach cancer) are at higher risk of developing cancer than others.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $307,053 |
| NIH project number | 5P01CA265772-02 |
| Project ID | NIH-10932174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with gastric intestinal metaplasia or those at high risk for gastric cancer.
✕Less likely to help
Patients without gastric intestinal metaplasia or those not at risk for gastric cancer may not benefit from this research.
What this research studies
This research focuses on understanding the behavior of gastric stem cells and their interactions with Helicobacter pylori, a bacteria that can lead to serious stomach conditions. By using a model of human stomach tissue, researchers aim to identify specific characteristics of high-risk gastric intestinal metaplasia (GIM), a precursor to gastric cancer. The study will involve creating organoids, which are miniaturized and simplified versions of the stomach, to explore genetic changes and cellular interactions that may influence cancer development. This approach could help clarify why some individuals with GIM develop cancer while others do not.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for gastric cancer.
How similar studies have gone: Previous research has shown promise in using organoid models to study cancer biology, indicating potential for success in this novel approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Amieva, Manuel R — Stanford University
- Study coordinator: Amieva, Manuel R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.