Investigating how stimulating the immune system can affect brain health in squirrel monkeys with Alzheimer's-like conditions.
Innate Immunity Stimulation Effects on Biomarkers, Cognition, and the Vascular Amyloid Proteome in a Squirrel Monkey Model of Sporadic CAA
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10872249
This study is looking at how boosting the body's natural immune response might help fight Alzheimer's disease by using a special immune receptor, and it's being tested on squirrel monkeys that show similar brain changes as people with Alzheimer's, to find safe ways to improve memory and thinking skills.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10872249 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how stimulating the innate immune system can help combat Alzheimer's disease (AD) by using a specific immune receptor, TLR9. The study utilizes squirrel monkeys, which naturally develop age-related brain changes similar to those seen in humans with AD, to test the effects of an immune-modulating treatment. By observing changes in behavior and brain biomarkers, the research aims to find a safe and effective way to address cognitive decline associated with Alzheimer's without causing harmful side effects. The findings could lead to new therapeutic strategies for managing AD in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those with cognitive decline.
Not a fit: Patients with other forms of dementia or those who do not have any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and reduce the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in using immune modulation to address Alzheimer's pathology, but this specific approach in squirrel monkeys is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHOLTZOVA, HENRIETA — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: SCHOLTZOVA, HENRIETA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease model, Alzheimer's disease pathology